Indy mutations and Drosophila longevity

Decreased expression of the Organic Dish fly and worm Indy genes extends longevity.The fly Indy gene and its mammalian homolog are transporters of Krebs cycle intermediates, with the highest rate of uptake for citrate.Cytosolic citrate has a role in energy regulation by affecting fatty acid synthesis and glycolysis.Fly, worm and mice Indy gene homo

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